Impacts from Non-Adherence to Meds Scripts

The National Library of Medicine part of NIH is a great source of information on meds and impact of non-patient adherence. Here are some of their thoughts. According to the FDA, “a majority of patients reported experiencing at least one side effect due to their medication (86.19%) resulting 60% lower complete adherence and significantly increased dropout rate of 74%.

The impacts of not taking meds include:

  • Lower adherence
  • Increased serious side effects
  • Higher dropout rate
  • Cross impacts of other meds
  • Relapse and rehospitaliztion

In addition, most side effects were associated with a significantly reduced likelihood of adherence. “Studies have suggested that medication side effects are associated with lower levels of adherence. Clinicians’ ratings of side effects are also associated with treatment discontinuation. Specifically, side effects such as medication-related obesity, distress over weight gain, and cognitive impairment have been associated with increased rates of nonadherence. Although other studies have examined adherence in real-world settings, few have studied the relationship between specific side effects and nonadherence. Moreover, there are no studies assessing the relationship between patient-reported side effects and self-reported adherence. This patient perspective is valuable as it provides insight into how the perception of side effects is associated with specific non-adherent behaviors; something that cannot be obtained from objective assessments of adherence. The primary aim of the current study is to assess the relationship between patient-reported antipsychotic side effects and self-reported medication adherence in a community-dwelling sample of patients with schizophrenia. A secondary aim is to assess the relationship between medication adherence and self-reported health resource utilization.”

This means if you don’t take your meds when you are supposed to, you may suffer in many ways including death.